Carlos A Fossati Selected Research

Brucellosis (Malta Fever)

3/2015	Immunization with Brucella VirB proteins reduces organ colonization in mice through a Th1-type immune response and elicits a similar immune response in dogs.
9/2012	Brucella abortus-infected macrophages modulate T lymphocytes to promote osteoclastogenesis via IL-17.
1/2011	Granulocyte-macrophage colony-stimulating factor- and tumor necrosis factor alpha-mediated matrix metalloproteinase production by human osteoblasts and monocytes after infection with Brucella abortus.
7/2010	Brucella-infected hepatocytes mediate potentially tissue-damaging immune responses.
11/2009	The polymeric antigen BLSOmp31 confers protection against Brucella ovis infection in rams.
1/2009	Immunization with recombinant Brucella species outer membrane protein Omp16 or Omp19 in adjuvant induces specific CD4+ and CD8+ T cells as well as systemic and oral protection against Brucella abortus infection.
5/2007	A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination.
10/2005	A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response.
10/2004	Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus.
9/2004	Occurrence and potential diagnostic applications of serological cross-reactivities between Brucella and other alpha-proteobacteria.

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Carlos A Fossati Research Topics

Disease

21	Infections 01/2017 - 03/2002
16	Brucellosis (Malta Fever) 03/2015 - 03/2002
4	Fabry Disease (Fabry's Disease) 05/2013 - 09/2006
3	Inflammation (Inflammations) 01/2017 - 10/2004
3	Hypersensitivity (Allergy) 08/2014 - 02/2002
3	Food Hypersensitivity (Food Allergy) 08/2014 - 09/2007
2	Milk Hypersensitivity (Milk Allergy) 01/2014 - 09/2007
2	Gaucher Disease (Gaucher's Disease) 12/2013 - 11/2012
1	Bone Resorption 02/2012
1	Arthritis (Polyarthritis) 09/2011
1	Communicable Diseases (Infectious Diseases) 01/2011
1	Bursitis (Adhesive Capsulitis) 12/2010
1	Necrosis 12/2010
1	Rheumatoid Arthritis 12/2010
1	Infectious Arthritis (Septic Arthritis) 12/2010
1	Hepatocellular Carcinoma (Hepatoma) 07/2010
1	Heart Diseases (Heart Disease) 08/2004
1	Chronic Disease (Chronic Diseases) 03/2002

Drug/Important Bio-Agent (IBA)

8	CytokinesIBA 01/2017 - 07/2002
7	Interleukin-8 (Interleukin 8)IBA 01/2017 - 07/2010
6	EnzymesIBA 05/2013 - 03/2002
5	Interleukin-6 (Interleukin 6)IBA 01/2017 - 09/2011
5	AntibodiesIBA 12/2010 - 03/2002
5	AntigensIBA 11/2009 - 03/2002
4	Proteins (Proteins, Gene)FDA Link 03/2015 - 07/2002
4	globotriaosylceramide (globotriosylceramide)IBA 05/2013 - 09/2006
4	Subunit VaccinesIBA 01/2009 - 10/2003
3	Immunoglobulin E (IgE)IBA 08/2014 - 09/2007
3	Matrix Metalloproteinases (MMPs)IBA 09/2011 - 07/2010
3	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 09/2011 - 09/2010
3	ImmunosorbentsIBA 09/2004 - 03/2002
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 02/2016 - 09/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2016 - 01/2011
2	Peptides (Polypeptides)IBA 01/2014 - 12/2005
2	Glucosylceramidase (Glucocerebrosidase)IBA 12/2013 - 11/2012
2	CollagenIBA 12/2013 - 09/2011
2	GalactosidasesIBA 05/2013 - 11/2011
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 10/2012 - 07/2010
2	Lipoproteins (Lipoprotein)IBA 02/2012 - 10/2004
2	alpha-Galactosidase (Beano)IBA 05/2009 - 09/2006
2	Membrane Proteins (Integral Membrane Proteins)IBA 01/2009 - 12/2005
1	Chemokine CCL5IBA 01/2017
1	Conditioned Culture MediaIBA 01/2015
1	beta-DefensinsIBA 01/2015
1	Cytidine Monophosphate (CMP)IBA 01/2014
1	EpitopesIBA 01/2014
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 12/2013
1	Matrix Metalloproteinase 1 (Interstitial Collagenase)IBA 12/2013
1	Neutral GlycosphingolipidsIBA 05/2013
1	Biological ProductsIBA 11/2012
1	Interleukin-10 (Interleukin 10)IBA 10/2012
1	Interleukin-17 (Interleukin 17)IBA 09/2012
1	CaspasesIBA 11/2011
1	Lysergic Acid Diethylamide (LSD)IBA 11/2011
1	ChemokinesIBA 09/2011
1	Interferon-gamma (Interferon, gamma)IBA 12/2010
1	Interleukin-1beta (Interleukin 1 beta)IBA 12/2010
1	GelatinasesIBA 12/2010
1	Cell Adhesion MoleculesIBA 07/2010
1	VaccinesIBA 11/2009
1	Brucella unlipidated outer membrane protein 19IBA 01/2009
1	Immunoglobulins (Immunoglobulin)IBA 09/2007
1	choloylglycine hydrolaseIBA 01/2007
1	Dihydrotachysterol (AT 10)IBA 01/2007
1	DNA VaccinesIBA 10/2005
1	Neurotransmitter Agents (Neurotransmitter)IBA 08/2004
1	6,7-dimethyl-8-ribityllumazine synthase (lumazine synthase)IBA 10/2003
1	ribosome releasing factor (ribosome recycling factor)IBA 03/2002
1	Recombinant ProteinsIBA 02/2002

Therapy/Procedure

3	Enzyme Replacement Therapy 11/2012 - 09/2006
1	Therapeutics 08/2014
1	Immunotherapy 01/2014